The Leagues Cup Round of 16 is set after the conclusion of the Round of 32, with Inter Miami drawing MLS powerhouse Columbus Crew.
The full matchups are as follows:
América vs St. Louis City
Toluca vs Colorado Rapids
Seattle Sounders vs Pumas
San Jose Earthquakes vs LAFC
FC Cincinnati vs Philadelphia Union
Mazatlán vs Cruz Azul
Tigres UANL vs New York City FC
Inter Miami vs Columbus Crew
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